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What is LKS syndrome?

Author

William Brown

Published Jun 23, 2026

What is LKS syndrome?

Landau-Kleffner syndrome (LKS) is a condition that shows up during childhood, causing difficulties with speech and seizures. Children with LKS lose the ability to talk and understand speech. This loss is called aphasia. Many children with LKS also have seizures, episodes of uncontrolled body movement.

What causes LKS?

This test uses large magnets and a computer to create images of tissues in the body. It may be done to check for other problems in the brain that may cause symptoms like those of LKS. Hearing tests (audiometry). These may be done to check for hearing loss that may cause signs like those of LKS.

What is LKS test?

LKS is diagnosed when a doctor sees clinical features that are consistent with the syndrome such as a loss of speech and an electroencephalogram (EEG) that shows specific kinds of seizure activity. Genetic testing can be used to confirm if there is a mutation in GRIN2A, but this testing is not done routinely.

Can Landau-Kleffner syndrome be cured?

What is the outlook for people with Landau-Kleffner syndrome? The outlook for recovering language is poor when LKS starts early in life or lasts for a long time without successful treatment. Seizures and EEG abnormalities go away in most cases.

Can laughing be a seizure?

Gelastic seizures is the term used to describe focal or partial seizures with bouts of uncontrolled laughing or giggling. They are often called laughing seizures. The person may look like they are smiling or smirking. Dacrystic seizures are focal or partial seizures when a person makes a crying sound.

How common is West syndrome?

The combination of the infantile spasms, age of onset and EEG pattern defines the epilepsy syndrome called, ‘West syndrome’. It is called this after Dr William West, who first described the condition in his 4-month-old son in 1841. West syndrome happens in about one in 2,500-3,000 children.

Is Landau-Kleffner syndrome autism?

A subgroup of children with autism after initially normal developmental (autistic regression) is of particular interest. Landau-Kleffner syndrome is a rare syndrome of unknown etiology….

Landau-Kleffner SyndromeAutistic Regression
Electrical status (EEG)YesNo
MutationsYes-GRIN2ANo

How is Landau-Kleffner syndrome diagnosed?

Landau-Kleffner syndrome is commonly diagnosed using an electroencephalogram (EEG). This is a scan that shows the brain’s electrical waves. Other diagnostic tests may be used.

What is a drop seizure?

Atonic seizures are a type of seizure that causes sudden loss of muscle strength. These seizures are also called akinetic seizures, drop attacks or drop seizures. The sudden lack of muscle strength, or tone, can cause the person to fall to the ground. The person usually remains conscious, and may not always fall down.

What is a giggle seizure?

People having a gelastic seizure (GS) sound like they are laughing or mumbling. This is an uncontrolled reaction caused by unusual electrical activity in the part of the brain that controls these actions. Gelastic seizures are named after the greek word for laughter, “gelastikos.”