What is metastatic porocarcinoma?
Abstract. Eccrine porocarcinoma (EPC) is a rare tumor. It develops from the intraepidermal ductal portion of the eccrine sweat gland. Metastatic disease is rare. We report a new case of metastatic eccrine porocarcinoma with a successful management and a good response to docetaxel.
Is porocarcinoma cancerous?
Porocarcinoma is a rare sort of skin cancer developing from sweat glands, specifically, it is a malignancy of the eccrine sweat glands [1]. Its etiology is not well understood. However, some studies have showed that the tumor developed from a pre-existing eccrine poroma.
What causes porocarcinoma?
The exact etiology of porocarcinoma is unknown, but like the benign poroma, it is known to arise from the acrosyringium. It is believed to either arise de novo or by malignant degeneration of a longstanding poroma. One study quoted 18% of porocarcinoma arise from poroma, while others claim 30-50%.
Is eccrine poroma cancerous?
Eccrine porocarcinoma is a rare malignancy of the eccrine sweat gland. It is usually found frequently on the lower extremities, and it affects both sexes equally usually in the sixth to seventh decade.
Is Porocarcinoma genetic?
While in poromas only few cases showed single mutated genes, porocarcinomas showed greater genetic heterogeneity with up to six mutated genes per case. Recurrent TP53 mutations were found in all porocarcinomas that harboured mutated genes.
What is a eccrine poroma?
Eccrine poroma is a benign tumor which arises from the intraepidermal portion of the eccrine sweat glands. It usually occurs as a solitary lesion in the extremity, with the foot and sole as a common site. It may present as a foot mass, ulcerative lesion, bleeding lesion, or suspected melanoma.
Where does adenocarcinoma usually start?
It starts in the epithelial tissue of your skin or internal organs. Adenocarcinoma is a subtype of carcinoma. It grows in the glands that line the insides of your organs.
What are the signs of adenocarcinoma?
Signs and Symptoms of Small Intestine Cancer (Adenocarcinoma)
- Pain in the belly (abdomen)
- Nausea and vomiting.
- Weight loss (without trying)
- Weakness and feeling tired (fatigue)
- Dark-colored stools (from bleeding into the intestine)
- Low red blood cell counts (anemia)
- Yellowing of the skin and eyes (jaundice)
What causes poroma?
A poroma is a relatively rare benign adnexal neoplasm that originates from the intra-epidermal portion of the sweat gland duct (the acrosyringium). It is thought to arise from the eccrine sweat gland, but apocrine features may be seen.
What is the prognosis of metastatic porocarcinoma?
Lymph node metastasis is found in 20% of newly diagnosed porocarcinomas and is associated with a mortality of 67%. Solid organ metastasis, including liver, lung, and bone, is seen in 10%. Recent studies have attempted to define specific clinical and histologic factors that may predict a poor prognosis.
What are the treatment options for porocarcinoma?
Patient Management Porocarcinoma is a challenge to treat. Early detection and definitive surgical excision is the only way to minimize mortality. Close clinical monitoring, including lymph node examination, is necessary, considering the high rate of local recurrence and lymph node metastasis.
What is the difference between porocarcinoma and eccrine poroma?
In contrast to the benign eccrine poroma, porocarcinoma does not show a predilection for locations with the highest density of eccrine glands, as it is most common on the lower extremities and is also observed on the head and neck, trunk, vulva, breast, nail bed, and upper extremities.
What is the difference between porocarcinoma and differential diagnosis?
Porocarcinomas are composed of two cell types including poroid and cuticular, while the other entities in the differential diagnosis are composed of a single cell type. However, porocarcinomas can be so undifferentiated that the diagnosis cannot be made with certainty.
